Carcinogen found in popular diabetes drug

Genotoxic impurities in drugs, known as nitrosamines, have been the topic of an ongoing FDA investigation. N-Nitrosodimethylamine, also known as NDMA, as a type of nitrosamine that is a known environmental contaminant. It has been classified as a probable human carcinogen. NDMA has been found in water and foods, including dairy products, vegetables and grilled and cured meats. In an official statement, the FDA announced that NDMA was found in a diabetes drug — Metformin.

According to the statement, the acceptable daily intake limit for NDMA in the U.S. is 96 nanograms. While the impurities were found in Metformin outside of the United States, the FDA is still investigating whether Metformin in the U.S. is also contaminated.

Janet Woodcock, M.D., director of the FDA’s Center for Drug Evaluation and Research, said in a statement “Our investigations, including our current investigation of metformin, take into account the medical necessity of the drug, how many Americans may take it, and whether there may be alternative treatments available. The American public can expect that we will act quickly to address any issue as soon as we find out about it.”

Woodcock noted that improved technology allows the agency to detect impurities in drug products. Several other drug products, including angiotensin II receptor blockers and ranitidine (Zantac) have also been found to contain small amounts of nitrosamines, resulting in recalls.

Woodcock added, “The FDA recommends prescribers continue to use Metformin when clinically appropriate, as the FDA investigation is still ongoing, and there are no alternative medications that treat this condition in the same way.”

For a list of the affected products, click here.

This isn’t the first time Metformin has made headlines.  Researchers from Albert Einstein College of Medicine in New York City used data from the Diabetes Prevention Program and the Diabetes Prevention Program Outcomes Study to look into the effects of metformin use on vitamin B12 levels. They found that nearly 20% of those taking Metformin had borderline low vitamin B12 levels compared to 10% of those taking a placebo.


By Dr Joseph Mercola / Physician and author

Dr. Joseph Mercola has been passionate about health and technology for most of his life. As a doctor of osteopathic medicine (DO), he treated thousands of patients for over 20 years.

Dr. Mercola finished his family practice residency in 1985. Because he was trained under the conventional medical model, he treated patients using prescription drugs during his first years of private practice and was actually a paid speaker for drug companies.

But as he began to experience the failures of the conventional model in his practice, he embraced natural medicine and found great success with time-tested holistic approaches. He founded The Natural Health Center (formerly The Optimal Wellness Center), which became well-known for its whole-body approach to medicine.

In 1997, Dr. Mercola integrated his passion for natural health with modern technology via the Internet. He founded the website to share his own health experiences and spread the word about natural ways to achieve optimal health. is now the world’s most visited natural health website, averaging 14 million visitors monthly and with over one million subscribers.

Dr. Mercola aims to ignite a transformation of the fatally flawed health care system in the United States, and to inspire people to take control of their health. He has made significant milestones in his mission to bring safe and practical solutions to people’s health problems.

Dr. Mercola authored two New York Times Bestsellers, The Great Bird Flu Hoax and The No-Grain Diet. He was also voted the 2009 Ultimate Wellness Game Changer by the Huffington Post, and has been featured in TIME magazine, LA Times, CNN, Fox News, ABC News with Peter Jennings, Today Show, CBS’s Washington Unplugged with Sharyl Attkisson, and other major media resources.

Stay connected with Dr. Mercola by following him on Twitter. You can also check out his Facebook page for more timely natural health updates.

(Source:; December 12, 2019;
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