NEW STUDY - Natural compounds outperform SSRIs in treating Depression

 Massive meta-analysis of 192 trials and 44 compounds finds saffron, curcumin, and omega-3s outperform antidepressants across the board — without the side effects.

Nicolas Hulscher, MPH

May 11, 2025

∙ Paid

By Nicolas Hulscher, MPH

As U.S. depression rates hit historic highs, new evidence points toward a safer, more effective path forward.

A major meta-analysis published in Psychological Medicine evaluated 192 randomized controlled trials with over 17,000 patients, comparing 44 nutraceuticals against each other, placebo, and antidepressant drugs (ADT). The results are striking — and deeply relevant for millions seeking alternatives to dangerous pharmaceutical anti-depressants such as SSRIs.

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By Nicolas Hulscher, MPH

@nichulscher

FOCAL POINTS (Courageous Discourse)

Epidemiologist at the McCullough Foundation.

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University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA

https://orcid.org/0009-0008-0677-7386

[email protected]

(Source: thefocalpoints.com; May 11, 2025; https://is.gd/Nh3RBE)
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