Many of those "incurable" conditions respond remarkably to DMSO

•DMSO can often significantly improve one’s vision, treat conditions such as macular degeneration, retinitis pigmentosa, and at times allow blind individuals to regain their sight. It is also often very helpful for sore and strained eyes and relieves excessive irritation and inflammation, along with many other eye conditions (e.g., cataracts).

•DMSO frequently treats a variety of ear conditions such as tinnitus, hearing loss, airplane ear, and a variety of infections inside the ear (e.g., otitis media).

•DMSO often is very helpful for sinusitis and a variety of infections of the nose and throat. Likewise, it is extremely helpful in dentistry, both for cleaning the mouth (e.g., by preventing bleeding gums), and by allowing the mouth to rapidly heal after dental surgeries.

•In this article, I will review the evidence supporting each of those uses, along with the data demonstrating the safety of these methods of DMSO administration and instructions on how to do them.

DMSO is a phenomenally effective medicine that can treat a wide variety of common, debilitating, or incurable conditions, which allowed it to rapidly take the country by storm (as both the public and the medical community saw its results and rapidly embraced it). Unfortunately, the widespread enthusiasm behind something that completely changed medicine and allowed people to care for themselves independently was unacceptable to the FDA. For the next two decades, the agency went to incredible lengths to suppress it (e.g., it actively defied Congress for over 16 years) and eventually made DMSO become a Forgotten Side of Medicine.

Note: extensive data shows that DMSO is a very safe substance with negligible toxicity.

In turn, one of the truly ironic things about this was that many of those who attacked DMSO later needed it. For example, the pioneer of DMSO discusses how Former President Lyndon Johnson sought his help in 1971 —after his FDA commissioner had just spent almost three years weaponizing the FDA against anyone wishing to use DMSO (which in turn set the stage for many of the police-state tactics the FDA would illegally use against natural medicine in the decades to come).

Note: in the previous article I erroneously stated this conversation took place in 1981 not 1971 (at which point LBJ was deceased).

I have now received hundreds of unbelievable reports from readers (which can be read here) of what DMSO did for them—many of which are almost identical to what people reported fifty years ago before the FDA wiped DMSO off the map.

For context, the majority of those reports were for the most common uses of DMSO, such as chronic pain, acute injuries, and arthritis (discussed further here). However, as discussed here, DMSO is also immensely valuable for a variety of circulatory and neurological disorders (e.g., varicose veins, hemorrhoids, Down Syndrome, and Parkinson’s)—all of which readers here reported significant improvement from. Likewise, (as discussed here) DMSO also helps various autoimmune conditions.

In this article, I will focus on another group of conditions DMSO was found to be extraordinarily effective—those within the head.

Note: headaches were covered in a previous article and will not be discussed here.

Cause or Effect?

There are two common ways to view medical problems someone has—as a specific disease process of a particular part of the body or as one manifestation of a systemic issue. Neither approach is entirely correct, as in some cases, you need one more than the other, but our medical system is very much biased towards the first one.

This, I would argue is in part because this makes medicine easier to practice (e.g., a specific set of symptoms goes with a specific drug rather than having to go the extra mile to figure out what is causing a nebulous set of symptoms), and in part because it makes it possible to sell far more patentable medicines (as by viewing each symptom as a different disease, far more diseases exist to market products for). Unfortunately, this also frequently lends itself to a situation where modern medicine “treats the symptoms rather than the cause.”

I personally believe that most chronic disease processes can have a variety of ways they manifest throughout the body. Typically the manifestation you see is a result of a pre-existing weakness in the body being the first spot to give out after a stressor is put on the entire body (e.g., one of the most common symptoms individuals with COVID vaccine injuries had was a pre-existing site of minor inflammation or an old scar becoming highly inflamed). Similarly, I believe this paradigm answers a critical question medicine never quite addresses—why do some people get so sick from the same thing that others quickly shrug off?

In turn, I’ve tried to focus on the forgotten areas of medicine that I believe often underlie various seemingly unrelated disease processes. For example, I believe that microcirculation is critical for health, but since it is not easy to measure, our focus instead has gone to blood pressure—which while sometimes useful for determining circulatory health, often is not. In turn, I’ve provided a variety of strategies for improving the microcirculation (e.g., improving the physiologic zeta potential). Beyond cardiovascular health improvement, many readers here who did that reported a variety of other chronic symptoms also having noticeable and unexpected improvement.
Note: all the previous also holds true for the cell danger response—a defensive mechanism cells go into where their mitochondria shut down that can only be treated by finding a way to coax the mitochondria out of it.

DMSO is also a systemic agent that has the ability to address some of the common root causes of disease. Because of how dramatically it helps injuries, arthritis, and chronic pain (of which I’ve received many remarkable testimonials from readers you can read here), those are its typical uses. However before long, many patients on DMSO would report some other chronic issue they never thought could improve also begin getting better (which likewise, many readers here have noticed). These reports caused the early pioneers of DMSO to begin researching other novel uses of DMSO.

In this article, I will look at the variety of remarkable benefits that have been observed for DMSO for conditions within the head. These results, I believe are a product of DMSO:

•Being able to increase microcirculation and treat circulatory or neurological disorders(e.g., strokes, traumatic head injuries, spinal cord injuries, and dementia or mental disability).

•Being able to re-awaken cells that were dormant or on the verge of dying due to a previous stressor.

•Being able to increase parasympathetic activity.

•Having strong anti-inflammatory properties.

• Having anti-bacterial properties.

•Being able to easily pass through biological membranes without harming them and spread throughout the body (while also carrying anything mixed with it into the body).

DMSO and the Eyes

Many DMSO users have noticed that their vision improved while they used it for something else (e.g., see this, this and this testimonial from a reader here), which in turn inspired physicians to begin applying it to the eyes of patients with vision problems.

Note: to my knowledge, every route of administration for DMSO except intrarectally has been researched. Of these, the only one that ever caused issues was nebulizing it (as rats who regularly breathed DMSO eventually developed toxicity). As a result, the DMSO field has recommended against nebulizing it, although I periodically read cases of individuals who had a positive response to nebulized DMSO

Ocular DMSO Distribution

The logic behind putting DMSO in the eyes is that a much stronger dose can get to the eyes than what would arise from systemic applications of DMSO. To evaluate DMSO’s distribution (and that of its metabolic breakdown products), radioactive forms of DMSO (DMSO synthesized from either 35S or 3H or both) were placed in animals and then their entire bodies were monitored for radiation emissions.

In one study, it was noted that while DMSO tended to distribute evenly throughout the body (typically being at a lower concentration in the tissue than in the blood), in the iris and ciliary body, it matched the blood’s concentration, while in the cornea (the surface of the eye), after 2 hours it was 2.2 times higher than the blood in rabbits and 4 times higher in rats. In other words, DMSO specifically concentrates in the cornea when administered into the body (after which it rapidly cleared), suggesting that DMSO is indicated for treating corneal and uveal diseases.
Note: concentrations did not increase with repeated administrations (indicating DMSO does not accumulate in the body).

More importantly, that study helps to explain why consuming DMSO can often directly impact and improve eye health.

Conversely, in another study, rats eyes were exposed to DMSO, and it was found regardless of the route of administration or the concentration used, DMSO rapidly cleared from the eyes:

This in turn, suggests that DMSO can rapidly extract things from the eyes that should not be there (e.g., excessive fluid) as whatever is in the eye will be drawn out into the rest of the body with the DMSO that leaves the eyes.

Note: DMSO has also long been used to preserve corneas, which will be transplanted to someone else, again indicating that DMSO is relatively non-toxic to the cornea.

DMSO Eye Safety

Since the idea of putting DMSO into the eyes understandably makes one uneasy, I’ve tried to locate all the safety data relating to this. Regarding the systemic administration of DMSO, there was a longstanding concern that DMSO could (temporarily) change the refractive index of the eyes. This finding was found in certain animals at very high doses of DMSO but never, despite extensive evaluation, found in monkeys or humans (e.g., see this study). For those interested, I summarized all the data on DMSO induced lens changes here, and the most detailed summary I found of exactly what changed in animal lenses can be found here.

Note: in humans, when DMSO was taken each day at 3-30 times the standard dose (achieved by covering the entire body in DMSO), 9% of participants experienced burning or aching eyes. This (like the previously mentioned effects) I suspect is due to the fact DMSO will concentrate in the cornea, but at the same time, realistically will never be an issue for a DMSO user because the effect only appears at very high doses (and has no real consequence besides the temporary irritation).

A few animal studies have been conducted which evaluated the effects of applying DMSO directly to animal eyes. The most detailed study put various combinations of steroids, 15% DMSO, or a saline placebo into rabbit’s eyes. A wide range of parameters inside the eyes were studied (e.g., regular body weights, intraocular pressure, retinoscopy, ophthalmoscopic, and biomicroscopic examinations alongside dissection of the eyes and examinations of their contents) alongside ones outside the eye (e.g., urine volume, urine composition, blood work, autopsies of organs) were then assessed. From this, it was found that 15% DMSO created no adverse effects, but did:

•Increase urine volume—DMSO alone increased it by 14.6%, while when added to varying concentrations of fluocinolone acetonide (a steroid), it increased by 4%, 29%, or 58% (which again illustrates that DMSO moves into the bloodstream after being applied to the eyes).

•Cause a slight decrease in urea in the aqueous humor of the eyes (which was small enough that it may have been due to chance).

•Decrease intraocular pressure (which is often quite helpful for the eyes).

Additionally, this study also applied 30% and 100% DMSO to rabbit eyes. In both cases, no evidence of change was seen in any part of the eye (the iris, cornea, lens, retina, conjunctiva, and lids), but 100% DMSO was observed to cause temporary lacrimation (tearing).

A separate paper on the known toxicology of DMSO also noted that:

•A Draize eye test (applying DMSO to an animal’s eye and keeping it on the eye) resulted in a slight conjunctivitis (eye irritation) which disappeared after 24 hours.

•One study found ocular instillation of 0.1 ml of 100% DMSO in rabbits caused reversible irritation of conjunctivae, while another author failed to observe this effect.

•Administering high doses of DMSO to rats (14.5g/kg) through the air resulted in hyperemia and eye inflammation.
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•In humans, two drops of greater than 50% DMSO applied to the eye caused a temporary burning sensation and vasodilation; concentrations of less than 50% exhibited no toxic effects.

Another study found that DMSO gave eye drops at 66% concentration to four patients, and one of the four experienced a temporary burning each time the drops were applied. Likewise, varying degrees of irritation and burning occurred as higher concentrations were used. However, no damage (as shown by a fluorescein stain) occurred to either their eyes or the animals in the study after ocular DMSO applications.

That same study also gave 4 rabbits 90% DMSO to the eyes six times a day, and then after 2 weeks, DMSO at 66% six times a day. At 90%, 2 of the rabbits experienced a temporary severe conjunctival injection (red eyes from swelling and inflammation of the blood vessels in the eye), but no keratitis (inflammation of the cornea) or damage to the lens was observed, and of the 6 total rabbits who received ocular DMSO, 3 had some degree of conjunctival irritation from DMSO.

I will now discuss two human studies that evaluated both the safety and efficacy of applying DMSO to the eyes, both of which found no toxicity from doing so.